UNC Health Care

Tag: Pharmacology

April 30, 2015

A BRAIN Initiative first: new tool can switch behavior ‘on’ and ‘off’

Using a new ‘chemogenetic’ technique invented at UNC, scientists turn neurons ‘on’ and ‘off’ to demonstrate how brain circuits control behavior in mice. This unique tool – the first to result from the NIH BRAIN Initiative – will help scientists understand how to modulate neurons to more effectively treat diseases.

Genetics, Neurology, Research, Technology, Treatment

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Gary Johnson

April 9, 2015

Researchers find new approach to treat drug-resistant HER2-positive...

Using human cancer cell lines, UNC scientists identified various ways that HER2-positive breast cancer tumors resist therapy, and they discovered a potential combination therapy to overcome multiple mechanisms of resistance and kill cancer cells.

Breast Cancer, Research, Treatment

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Thomas L. Kash

March 9, 2015

Protein in the brain can ‘put the brakes’ on binge drin...

A new study led by UNC researchers identifies both where in the brain and how a protein in the brain, called Neuropeptide Y or NPY, can act to suppress binge alcohol drinking. These findings suggest that restoring NPY may be useful for treating alcohol use disorders and may also protect some individuals from becoming alcohol dependent.

Neurology, Research, Substance Abuse

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February 4, 2015

Potential pancreatic cancer treatment could increase life expectancy

Device that drives drugs into solid tumors that are poorly vascularized opens the possibility of life-saving surgeries in cancer patients. James Byrne, PhD, a medical student and member of Joseph DeSimone’s lab, led the research by constructing the device and examining its ability to deliver chemotherapeutic drugs effectively to pancreatic cancer tumors, as well as two types of breast cancer tumors.

Cancer, Research, Treatment

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Bryan L. Roth

December 23, 2014

Roth’s novel research technique, DREADDs, lands him on Top 10 List

The National Institute of Mental Health director Tom Insel recognized Byran L. Roth, MD, PhD, for his innovative research tool.

Awards, Mental Health

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Orrin Stone/Photo by Max Englund

December 11, 2014

Platforms for Proteins

Graduate student Orrin Stone is creating molecular tools to pinpoint how and when cellular pathways trigger cell movement – or, in cancer, metastasis.

Cancer, Cell Biology, Devices, Innovation

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(L to R) Nancy L. Allbritton

December 2, 2014

UNC School of Medicine researchers elected AAAS fellows

The scientists join 65 UNC colleagues as fellows of the American Academy for the Advancement of Science.

Awards, Ebola, Research

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Bryan Roth

October 1, 2014

UNC researchers receive $2.85-million NIH BRAIN Initiative grant

Led by Bryan L. Roth, MD, PhD, three UNC labs will develop the next generation neuroscience tool-kit to accelerate novel treatments for neuropsychiatric and a host of other diseases.

Grants, Neurology

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Rajarshi Choudhury

April 29, 2014

UNC researchers discover “master regulator” role for little-known p...

Previously thought to only play a role in male fertility, the protein DAZAP1 has now been shown to be a major player in how genes are expressed; in cell culture experiments it stifled the progression of several types of cancer cells.

Cancer, Research

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A digital version of the high resolution crystal structure of the delta opioid receptor with the sodium ion at the center in blue.

January 12, 2014

Solving a 40-year-old mystery, UNC researchers find new route for b...

New targeted therapies for pain, Parkinson's disease, and depression carry the promise of greater benefit for patients without serious side effects.

Pain, Research

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Juan Song

November 26, 2013

A Real Mindbender

UNC neuroscientist Juan Song discovers how baby neurons stay alive, a key finding for understanding neurodegenerative diseases, such as Alzheimer’s

Alzheimer's, Neurology

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