UNC Health Talk

Tag: Pharmacology

Center: a molecule of LSD bound to a larger serotonin receptor. The lid" that keeps LSD bound so long is the orange bar running through the center."

January 26, 2017

This is LSD attached to a brain cell serotonin receptor

For the first time, UNC School of Medicine researchers crystalized the structure of LSD attached to a human serotonin receptor of a brain cell, and they may have discovered why an “acid trip” lasts so long.

Neurology, Research, Substance Abuse

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Bryan Roth

September 15, 2016

Researchers build a better opioid painkiller from scratch

The new compound could reduce overdoses and possibly curb addiction, while addressing the needs of millions of people suffering with chronic pain.

Research, Treatment

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Illustration of a man on a blue background with colorful pills falling into his open head.

August 24, 2016

How do antidepressants trigger fear and anxiety?

UNC School of Medicine researchers map the anxiety circuit in the brain and use a compound to limit fearful behavior – an acute side effect of commonly prescribed SSRI antidepressants.

Mental Health, Research

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Jonathan Schisler

April 5, 2016

New clues in the quest to prevent clogged arteries

UNC School of Medicine researchers have found a protein that appears to protect against coronary artery disease in older people with surprisingly clear arteries.

Studies, Vascular Health

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Janet Rubin

November 12, 2015

UNC researchers find new way to force stem cells to become bone cells

Potential therapies based on this discovery could help people heal bone injuries or set hardware, such as replacement knees and hips.

Genetics, Research, Treatment

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Bryan Roth

November 9, 2015

Researchers shed pharmacological light on “dark” cellular receptors

UNC and UCSF labs create a new research tool to find homes for two orphan cell-surface receptors, a crucial step toward finding better therapeutics and causes of drug side effects.

Genetics, Research

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April 30, 2015

A BRAIN Initiative first: new tool can switch behavior ‘on’ and ‘off’

Using a new ‘chemogenetic’ technique invented at UNC, scientists turn neurons ‘on’ and ‘off’ to demonstrate how brain circuits control behavior in mice. This unique tool – the first to result from the NIH BRAIN Initiative – will help scientists understand how to modulate neurons to more effectively treat diseases.

Genetics, Neurology, Research, Technology, Treatment

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Gary Johnson

April 9, 2015

Researchers find new approach to treat drug-resistant HER2-positive...

Using human cancer cell lines, UNC scientists identified various ways that HER2-positive breast cancer tumors resist therapy, and they discovered a potential combination therapy to overcome multiple mechanisms of resistance and kill cancer cells.

Breast Cancer, Research, Treatment

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Thomas L. Kash

March 9, 2015

Protein in the brain can ‘put the brakes’ on binge drin...

A new study led by UNC researchers identifies both where in the brain and how a protein in the brain, called Neuropeptide Y or NPY, can act to suppress binge alcohol drinking. These findings suggest that restoring NPY may be useful for treating alcohol use disorders and may also protect some individuals from becoming alcohol dependent.

Neurology, Research, Substance Abuse

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February 4, 2015

Potential pancreatic cancer treatment could increase life expectancy

Device that drives drugs into solid tumors that are poorly vascularized opens the possibility of life-saving surgeries in cancer patients. James Byrne, PhD, a medical student and member of Joseph DeSimone’s lab, led the research by constructing the device and examining its ability to deliver chemotherapeutic drugs effectively to pancreatic cancer tumors, as well as two types of breast cancer tumors.

Cancer, Research, Treatment

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Bryan L. Roth

December 23, 2014

Roth’s novel research technique, DREADDs, lands him on Top 10 List

The National Institute of Mental Health director Tom Insel recognized Byran L. Roth, MD, PhD, for his innovative research tool.

Awards, Mental Health

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